GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs10935120 | 1 | rs6439487 | chr3:134260860 | CEP63 | chr3:134204575-134293852:+ | 0.23 | 3.93 | 0.000102 | Height |
| BLCA | cis | rs344081 | 1 | rs6441104 | chr3:156681441 | LEKR1 | chr3:156544076-156763918:+ | -0.46 | -6.47 | 3.03E-10 | Bone mineral density |
| BLCA | cis | rs9876781 | 1 | rs6442119 | chr3:48440178 | TREX1 | chr3:48501186-48509043:+ | -0.2 | -4 | 7.48E-5 | Longevity |
| BLCA | cis | rs9876781 | 1 | rs6442120 | chr3:48464503 | TREX1 | chr3:48501186-48509043:+ | -0.19 | -3.86 | 0.000134 | Longevity |
| BLCA | cis | rs1401999 | 1 | rs6443927 | chr3:183718864 | ABCC5 | chr3:183637726-183735727:- | -0.19 | -3.83 | 0.00015 | Anterior chamber depth |
| BLCA | cis | rs10461617 | 1 | rs6450408 | chr5:56098146 | C5orf35 | chr5:56205103-56213010:+ | 0.71 | 10.45 | 1.17E-22 | Type 2 diabetes |
| BLCA | cis | rs10461617 | 1 | rs6450409 | chr5:56101399 | C5orf35 | chr5:56205103-56213010:+ | 0.65 | 9.93 | 7.97E-21 | Type 2 diabetes |
| BLCA | cis | rs1577917 | 1 | rs6454513 | chr6:86720049 | SNHG5 | chr6:86386726-86388451:- | 0.55 | 9.8 | 2.22E-20 | Response to antipsychotic treatment |
| BLCA | cis | rs6458307 | 1 | rs6458307 | chr6:42731115 | PEX6 | chr6:42931613-42946981:- | -0.31 | -4.51 | 8.62E-6 | Bipolar disorder |
| BLCA | cis | rs9369898 | 1 | rs6458685 | chr6:49379536 | CENPQ | chr6:49431096-49460820:+ | -0.4 | -8.67 | 1.24E-16 | Homocysteine levels |
| BLCA | cis | rs9369898 | 1 | rs6458688 | chr6:49406056 | CENPQ | chr6:49431096-49460820:+ | -0.39 | -8.57 | 2.55E-16 | Homocysteine levels |
| BLCA | cis | rs9473555 | 1 | rs6458690 | chr6:49411619 | CENPQ | chr6:49431096-49460820:+ | -0.29 | -5.87 | 9.23E-9 | Folate pathway vitamin levels |
| BLCA | cis | rs9473555 | 1 | rs6458690 | chr6:49411619 | MUT | chr6:49398994-49431031:- | 0.28 | 5.46 | 8.45E-8 | Folate pathway vitamin levels |
| BLCA | cis | rs9473555 | 1 | rs6458694 | chr6:49445306 | CENPQ | chr6:49431096-49460820:+ | -0.28 | -5.56 | 4.93E-8 | Folate pathway vitamin levels |
| BLCA | cis | rs9473555 | 1 | rs6458694 | chr6:49445306 | MUT | chr6:49398994-49431031:- | 0.28 | 5.5 | 6.93E-8 | Folate pathway vitamin levels |